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Proteomics Scientist In Targeted Protein Degradation Research

Berlin-BUCH | Max-Delbrück-Center

The Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association is an international biomedical research center dedicated to understanding the molecular mechanisms of health and disease with the goal to devise new diagnostics and medicines. The MDC is a member of the Helmholtz Association, Germany's largest scientific organization, and offers an engaging research environment with cutting-edge research infrastructure. Currently, ~1250 employees and ~500 guest scientists work at the Berlin-Buch and Berlin-Mitte campuses. Our diverse workforce is a core strength that inspires creativity and innovation at the MDC.

The MDC is committed to improving human health through transformative biomedical research. Our goal is to pioneer discoveries for preventing, treating, and ultimately curing disease.

The targeted protein degradation research program is seeking for a proteomics scientist investigating how to reprogram the proteostasis network.

Job Description

A post-doctoral position is available under the supervision of Dr. Ilaria Piazza to work in close collaboration with scientists at the Vienna BioCenter. The selected candidate will work on a research project focused on targeted protein degradation, which is part of a special research consortium funded by the Austrian and German Science funds (FWF and DFG). The position is based in the Piazza laboratory located at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) in Berlin and requires close collaboration with all our consortia partners in Vienna.

We are seeking a highly motivated postdoctoral fellow to join our dynamic team focused on elucidating the intricacies of the ubiquitin-proteasome system (UPS). The successful candidate will play a key role in a ground-breaking project aimed at developing a new structural proteomics method to characterize candidate molecular glues and their protein-protein interactions binding interfaces. With proof-of-concept already established, you will work to refine and optimize the method to achieve broad applicability and high reproducibility. You will have the opportunity to apply this novel approach to explore pressing biomedical questions, such as finding new drugs to advance treatments for human tumors and immunotherapies.

Here are the key responsibilities required for the job:

  • Structural Proteomics Research: you will employ state-of-the-art instrumentation, including mass spectrometers, for the global analysis of protein-protein interactions.
  • Technology Advancement: you will contribute to the development and enhancement of structural proteomics technologies, particularly those relevant to drug development and PPI-targeting drugs.
  • Investigation of the proteostasis network: you will Investigate how cellular stress influences the E3 ligase interaction network focusing on the HECT domain protein HUWE1 in various tissues, including neural stem cells.
  • Druggability Testing: you will investigate how small molecules can be used to chemically reprogram the association of distinct E3 ligases and proteins of interest, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner.

Requirements

  • Ph.D. in Structural Biology, Biochemistry, or a related field.
  • Proven experience in structural proteomics and protein-protein interaction studies.
  • Expertise in utilizing cutting-edge technologies for mapping protein-small molecule interfaces.
  • Strong background in cellular biology and a keen interest in proteostasis and the and ubiquitin-dependent degradation pathways.
  • Experience in working with consortia partners and collaborative research environments is desirable.
  • A strong publication record as primary author, and excellent communication skills in English.

The successful candidate will take a strong lead in the experimental design and data interpretation in the context of an international cross-disciplinary collaboration. If you are a dedicated researcher with a desire to drive innovation in the field, we encourage you to apply for this exciting position.

We offer

  • international working environment with communication in English and German
  • interesting career opportunities and a range of opportunities for further qualification and training
  • Compatibility of family and career certified by the workandfamily audit (“berufundfamilie audit”)
  • Support for "New Berliners" through the MDC Welcome & Family Office
  • On-campus health and fitness center

You also benefit from:

  • a remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
  • flexible working hours and childcare support
  • Subsidy for the job ticket as well as discounts in the campus canteen

Further Information:



Team:


Application Period:
February 29, 2024


Workplace:
MDC Berlin-Buch


Salary:
Remuneration will be according to the TVöD Bund, depending on the personal requirements, up to the fee group E13.


Employment volume:
Full Time
The working hours per week are 39 hours.


Desired starting date:
March 15, 2024


Limitation:
Fixed Term
Appointments are made for an initial period of 2 years with possibility of extension.


Contact:
Ilaria Piazza
AG Piazza


Commitment to Equity, Diversity and Inclusion:
MDC values diversity and is committed to fostering an inclusive, fair and open environment that allows everyone to grow and flourish. All qualified applicants will receive equitable consideration for employment based on their experience and qualifications, and will not be discriminated against on the basis of national or ethnic origin, religion, sexual orientation, gender identity, disability, age, or other personal characteristics. We recognize that creating diverse teams that represent a broad range of experiences, perspectives and backgrounds strengthen our work and research. We welcome applications from open-minded people who embrace working together in a diverse environment. Applications from severely disabled people will be given particular consideration.


Application:
Enquiries about the position should be addressed to ilaria.piazza@mdc-berlin.de
Please use our online portal and submit your application including a cover letter, CV  and other relevant attachments. The starting dates for the positions are negotiable.


Apply now