is an Einstein BIH Visiting Professor funded by Charité Foundation and Einstein Foundation. The Pombo and Nicodemi labs cooperate on understanding chromatin folding and gene regulation in disease associated genomic regions by use of physics models, computer simulations and high-throughput data production and analysis.
BIMSB was initiated and developed by Nikolaus Rajewsky (BIMSB Scientific Director). BIMSB is an expansion of the MDC into Medical Systems Biology.
BIMSB received, starting 2008, 19 Mio € kick-off funding through the competitive federal initiative “Spitzenforschung in den neuen Bundesländern” (BMBF & Senate Berlin). After a highly successful external peer-review, the BMBF decided to provide additional institutionalized funding for BIMSB (17.5 Mio € /year + 2.5 Mio € /year MDC “Eigenanteil”).
The Humboldt University included BIMSB in their successful participation in the “Exzellenzinitiative” and provided the real estate on the new life science Campus in Berlin Mitte. This neighborhood is important for the BIMSB scientific mission and promotes collaborations between the HU and the MDC. The BMBF provides additional money for the new building (33.5 Mio €). So far, BIMSB researchers newly acquired additional 28.7 Mio € in competitive third-party funds by the BMBF, DFG, EC, HFSP, NIH, industry, BIH and DZHK.
Total external funding to date: 47.7 Mio € (competitively acquired) + 86 Mio € (institutionalized funding by the BMBF).
Medical systems biology research combines various disciplines, technologies and experts. Current regional collaboration partners include the, , , the DFG research center for applied Mathematics , the , the and others. BIMSB is part of the of the HU, supporting many collaborations between the local research institutions and educational activities in the field of systems biology.
The scientific concept of BIMSB includes medical systems approaches as well as basic questions of gene regulation and collaborations with translational and clinical academic partners are in place. This includes the integrative approaches funded by the. With the Berlin Institute of Health (BIH), the Max Delbrück Center for Molecular Medicine (MDC) and the Charité - Universitätsmedizin Berlin have joined forces to build a research space for translational research and overarching systems medicine approaches to bridge the gap between basic research and clinical application. BIMSB will be a strong collaborating partner for BIH groups and projects as well as for all academic partners mentioned above.
At the national level, BIMSB participates in theas part of the . Also, BIMSB will be a key hub in the National Bioinformatics Infrastructure for RNA Biology (de.NBI, funded by the BMBF), to be established in 2015.
BIMSB is fostering and maintaining institutional collaborations with national and international research institutes, universities, and other organizations to facilitate joint research projects, staff exchange, access to cutting-edge technologies, and development of joint training activities. Close collaboration exists e.g. with thefor the as well as with the . Individual PIs hold multiple collaborations and grants with other European and international institutes and groups.
At the European level, BIMSB is involved in the European Strategy Forum on Research Infrastructures (ESFRI).is a strategic instrument to develop the scientific integration of Europe and to strengthen its international outreach. It supports a coherent and strategy-led approach to policy-making on research infrastructures in Europe, and facilitates multilateral initiatives leading to the better use and development of research infrastructures, at EU and international level. BIMSB is currently partner in the ESFRI initiative (Infrastructure for Systems Biology in Europe), aiming to build a distributed infrastructure of interconnected systems biology centres providing resources and services to all European life scientists.
For more information on ESFRI or other European activities please contact.
Major awards and prizes of group leaders
Nikolaus Rajewsky, European Commission Training Grant
Roland Schwarz, Prize of the BBAW, donated by the Monika Kutzner Foundation
Jan Philipp Junker, European Research Council Starting Grant
Markus Landthaler, GlaxoSmithKline Foundation’s Science Prize
Jan Philipp Junker, ARCHES prize of the Minerva Stiftung in collaboration with Erez Levanon, Bar-Ilan University, Israel
Baris Tursun, European Research Council Starting Grant
Nikolaus Rajewsky, Human Frontier Science Program in collaboration with 3 international scientists
Nikolaus Rajewsky, Gottfried Wilhelm Leibniz Prize of the German Research Foundation
Nikolaus Rajewsky, Science Award of the Governing Mayor of Berlin
Fellowship and awards of young researchers
Elena Torlai Triglia, Ana Pombo Lab, Open Data Award
Jonas Peters, Landthaler Lab, Friedrich-Naumann-Stiftung Scolarship
Roberto Moreno-Ayala, JP Junker lab, CONACYT Postdoctoral Research Fellowship
Yuliang Qu, B Tursun lab, Chinese Scholarship Council PhD Scholarship
Nida ul Fatima, B Tursun lab, NUST Program
Mei He, B Tursun lab, Chinese Scholarship Council PhD Scholarship
Camilla Ciolli Mattioli, M Chekulaeva lab, Peter and Traudl Engelhorn Stiftung PhD Fellowship, Dissecting the roles of miRNAs in local translation
Scott Lacadie, U Ohler lab, Stiftung Charité BIH Delbrück Fellowship, Dynamics and functions of the enhancer landscape during zebrafish development and cardiogenesis
Christin Stottmeister, N Rajewsky lab, Böhringer Ingelheim Fonds PhD Fellowship, The role of circular RNAs in neuronal differentiation and disease
Marta Mauri, M Chekulaeva lab, DAAD PhD Scholarship, Towards a functional interactome of TNRC6C protein
Stefanie Grosswendt, N Rajewsky lab, EMBO Short-term Fellowship
Marlon Kazmierczak, B Tursun lab, MDC Fellowship Committee PhD Fellowship, Direct reprogramming of distinct cell types in C. elegans into GABAergic motor neurons
Neelanjan Mukherjee, U Ohler lab, Marie Curie IIF Postdoctoral Fellowship, RNARegMap condition specific RNA regulatory maps
Caibin Sheng, A Loewer lab, Chinese Scholarship Council PhD Scholarship, Investigating signaling dynamics and pathway interaction using knock-in fluorescent reporters
Tao Chen, W Chen lab, Chinese Scholarship Council PhD Scholarship, Indentification and functional charaterisation of a de novo point mutation identifed in a patient with microephaly
Qingsong Gao, W Chen lab, Chinese Scholarship Council PhD Scholarship, Predominant contributionh of a cis-regulatory divergence in the evolution of mouse alternative splicing
Oktay Kaplan, B Tursun lab, Helmholtz Postdoc Program & EMBO Long-term Fellowship, Overcoming epigenetic barriers for reprogramming cells
Miha Milek, M Landthaler lab, Marie Curie IEF Postdoctoral Fellowship, RNA biology
Benedikt Obermayer, N Rajewsky lab, MDC Fellowship Committee Delbrück Fellowship, Evolutionary modeling and inference in computational systems biology
Mei-Sheng Xiao, W Chen lab, Chinese Scholarship Council PhD Scholarship, Genome wide analysis of alternative polyadentation
Erik McShane, M Selbach lab, MDC Fellowship Committee PhD Fellowship
Yasuhiro Murakawa, M Landthaler lab, DAAD PhD Scholarship, Functional characterisation of the human RNA-binding protein RC3H1 and Endoribonuclease DICER1