Group Picture in Israel 2013

Students

Class of 2018

David Gomes

    Elucidation of CTCF-mediated spatial chromatin organization on IgK repertoire and asynchronous replication

    • Lab of Yehudit Bergman, Hebrew University of Jerusalem
    • Co-mentor: Klaus Rajewsky, Max Delbrück Center for Molecular Medicine

    Stefania Tocci

    New insights for the role of Sharpin in cancer

    • Lab of Ze'ev Ronai, Technion - Israel Institute of Technology
    • Co-mentor: Claus Scheidereit, Max Delbrück Center for Molecular Medicine

     

    Class of 2017

    Elle Koren 

    The Role of Sept4/ARTS in Intestinal Regeneration and Tumorigenesis

    • Lab of Yaron Fuch, Technion - Israel Institute of Technology
    • Co-mentor: Walter Birchmeier, Max Delbrück Center for Molecular Medicine

    Publications

    • Yosefzon Y, Soteriou D, Feldman A, Kostic A, Koren E, Ankawa R, Brown S, Sedov E, Glaser F, Fuchs Y. Caspase-3 regulates YAP-dependent organ size and Skin Regeneration (2018). Molecular Cell 70, 573–587.
    • Koren E. and Fuchs Y. The bad seed: cancer stem cells in tumor development and resistance (2016). Drug Resistance Updates 28, 1-12.

    Cristina Brischetto

     Regulation of autophagy by IKK/NFκB signalling pathway after DNA damage 

    • Lab of Claus Scheidereit, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Yinon Ben-Neriah, Hebrew University of Jerusalem

    Patrick Mucka

    Mechanisms of posttranscriptional gene regulation by IkB kinases

    • Lab of Claus Scheidereit, Max Delbrück Center for Molecular Medicine
    • Co-Mentor: Ze'ev Ronai, Technion - Israel Institute of Technology

    Hazel Quinn

    The Role of Sonic-Hedgehog in the Development of Wnt-Met Driven Basal-Like Breast Cancer

    • Lab of Walter Birchmeier, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Yaron Fuchs, Technion - Israel Institute of Technology

     

    Class of 2016

    Alba Ferri Blázquez

    Molecular analysis of Ubiquitin modifications on Serine/Threonine residues

    • Lab of Thomas Sommer, Max Delbrück Center for Molecular Medicine
    • Co-mentors: Michael Glickman & Aaron Ciechanover, Technion - Israel Institute of Technology

    Eric Hung

    CKI as a therapy target in the haematopoiesis malignancies

    • Lab of Yinon Ben-Neriah, Hebrew University of Jerusalem
    • Co-mentors: Klaus Rajewsky, Max Delbrück Center for Molecular Medicine & Clemens Schmitt, Charité Universitätsmedizin

     

    Class of 2015

    Alon Appleboim

    A systematic approach to RNA effects on cellular localization

    • Lab of Nir Friedman, Hebrew University of Jerusalem
    • Co-mentor: Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine

    Publications

    • Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou HJ, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, Müller CW, Kelleher NL, Friedman N, Bolon DN, Rando OJ, Kaufman PD (2017). A synthetic biology approach to probing nucleosome symmetry. eLife 6.
    • Weiner A, Hsieh TH, Appleboim A, Chen HV, Rahat A, Amit I, Rando OJ, Friedman N (2015). High-resolution chromatin dynamics during a yeast stress response. Mol. Cell 58, 1-16
    • Geffen Y, Appleboim A, Gardner RG, Friedman N, Sadeh R, Ravid T. Mapping the Landscape of a Eukaryotic Degronome (2016). Mol. Cell 63(6), 1055-65

    Nagarjuna Reddy Pamudurti

    Biogenesis and function of circRNAs in Drosophila

    • Lab of Sebastian Kadener, Hebrew University of Jerusalem
    • Co-mentor: Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine

    Publications

    • Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, Shenzis S, Samson M, Dittmar G, Landthaler M, Chekulaeva M, Rajewsky N, Kadener S (2017); Translation of CircRNAs. Mol Cell 66(1):9-21.e7.
    • Ashwal-Fluss R*, Meyer M*, Pamudurti NR*, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N, Kadener S (2014). circRNA biogenesis competes with pre-mRNA splicing. Mol. Cell 46, 55-56 | *equal contribution
    • Pamudurti NR*, Bartok O*, Jens M*, Ashwal-Fluss R*, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, Shenzis S, Samson M, Dittmar G, Landthaler M, Chekulaeva M, Rajewsky N, Kadener S (2017). Translation of CircRNAs. Mol. Cell 66(1), 9-21 | *equal contribution

    Yana Rozevsky

    Single-molecule quantification of the cancer biomarkers KRAS, MACC1 and S100A4 using solid-state nanopores

    • Lab of Amit Meller, Technion - Israel Institute of Technology
    • Co-mentor: Ulrike Stein, Charité - Universitätsmedizin / Max Delbrück Center for Molecular Medicine

     

    Class of 2014

    Dhana Friedrich

    Oscillatory transcription factors and stochastic gene expression

    • Lab of Alexander Loewer, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Amit Meller, Technion - Israel Institute of Technology

    Christian Lips

    Characterization of membrane-associated ubiquitin ligases 

    • Lab of Thomas Sommer, Max Delbrück Center for Molecular Medicine
    • Co-mentors: Michael Glickman/Aaron Ciechanover, Technion - Israel Institute of Technology

    Publications

    • Haralampiev I, Schade M, Chamiolo J, Jolmes F, Prisner S, Witkowski PT, Behrent M, Hövelmann F, Wolff T, Seitz O, Herrmann A (2017). A Fluorescent RNA Forced-Intercalation Probe as a Pan-Selective Marker for Influenza A Virus Infection. Chembiochem 18(16):1589-1592.

    Waleed Minzel

    Regulation of quiescence entry and exit of hematopoietic stem cells

    • Lab of Yinon Ben-Neriah, Hebrew University of Jerusalem
    • Co-mentor: Clemens Schmitt, Charité - Universitätsmedizin Berlin

    Publications

    • Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, Mercurio F, Li D, Vacca J, Kaushansky N, Shlush L, Oren M, Levine R, Pikarsky E, Snir-Alkalay I, Ben-Neriah Y (2018). Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 [ahead of print]
    • Haddad A, Flint-Ashtamker G, Minzel W, Sood R, Rimon G, Barki-Harrington L (2012). Prostaglandin EP1 receptor down-regulates expression of cyclooxygenase-2 by facilitating its proteasomal degradation. J. Biol. Chem. 287(21), 17214-17223
    • Sood R, Minzel W, Rimon G, Tal S, Barki-Harrington L (2014). Down-regulation of cyclooxygenase-2 by the carboxyl tail of the angiotensin II type 1 receptor. J. Biol. Chem. 289(45), 31473-31479

    Simon Prisner

    Molecular mechanisms of viral infection

    •  Lab of Andreas Herrmann, Humboldt-Universität zu Berlin
    • Co-mentor: Amit Meller, Technion - Israel Institute of Technology

    Publications

    • Jin S, Kedia N, Illes-Toth E, Haralampiev I, Prisner S, Herrmann A, Wanker EE, Bieschke J (2016). Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity. J Biol Chem. 291(37), 19590-606 

    Christin Suenkel (geb. Stottmeister)

    Exploring circRNA functions in Neuronal Differentiation and Disease

    • Lab of Nikolaus Rajewsky, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Sebastian Kadener, Hebrew University of Jerusalem

    Publications

    • Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, Shenzis S, Samson M, Dittmar G, Landthaler M, Chekulaeva M, Rajewsky N, Kadener S (2017); Translation of CircRNAs. Mol Cell 66(1):9-21.e7.
    • Rybak-Wolf, A*, Stottmeister, C*, Glažar, P*, Jens, M, Pino, N, Giusti, S, Hanan, M, Behm, M, Bartok,  O, Ashwal-Fluss, R, ..., Kadener S, Rajewsky, N (2015). Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Mol. Cell 1–16. | *equal contribution

     

    Class of 2013

    Dámaris Anell Rendon

    Proteotoxicity in therapy-induced senescence

    • Lab of Clemens Schmitt, Max Delbrück Center for Molecular Medicine / Charité Virchow Klinikum MKFZ
    • Co-mentor: Michael Glickman, Technion - Israel Institute of Technolog

    Publications

    • Bouzas-Rodríguez J, Zárraga-Granados G, Sánchez-Carbente MdR, Rodríguez-Valentín R, Gracida X, Anell-Rendón D, Covarrubias L, Castro-Obregón S (2012). The nuclear receptor NR4A1 induces a form of cell death dependent on autophagy in mammalian cells. PLoS ONE 7(10), e46422

    Upasana Das Adhikari

    p53 control of intestinal stem cell fate

    • Lab of Yinon Ben-Neriah, Hebrew University of Jerusalem
    • Co-mentors: Walter Birchmeier and Alexander Loewer, Max Delbrück Center for Molecular Medicine

    Publications:

    • Morgenstern Y*, Das Adhikari U*, Ayyash M, Elyada E, Tóth B, Moor A, Itzkovitz S, Ben-Neriah Y (2017). Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance. EMBO J. 36(20):3046-306. *equal contribution

    Alumni

    Jane Joy Thomas

    Role of RNF4 in oncogene activation

    • Lab of Amir Orian, Technion - Israel Institute of Technology
    • Co-mentor: Walter Birchmeier, Max Delbrück Center for Molecular Medicine

    Publications

    • Thomas JJ, Rekha Chandra MR, Sharma P (2010). Dextran glycidyltrimethylammonium chloride conjugate/DNA nanoplex: A potential non-viral and haemocompatible gene delivery system. Int. Journal of Pharmaceutics 389(1-2), 195-206
    • Thomas JJ, Rekha Chandra MR, Sharma P (2010). Unraveling the intracellular efficacy of Dextran-Histidine Polycation as an efficient non-viral gene delivery system. Mol. Pharmaceutics (ACS) 9(1), 121-134
    • Thomas JJ, Rekha Chandra MR, Sharma P (2012). Dextran-protamine polycation: An efficient nonviral and haemocompatible gene delivery system. Colloids and Surfaces B: Biosurfaces 81(1), 195-205
    • Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MX, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A (2016). RNF4-Dependent Oncogene Activation by Protein Stabilization. Cell Rep. 16(12), 3388-400

    Naama Flint Brodsly

    Elucidating a genetic network that maintains the differentiated identity of enterocytes and gut homeostasis

    • Lab of Amir Orian, Technion - Israel Institute of Technology
    • Co-mentor: Walter Birchmeier, Max Delbrück Center for Molecular Medicine

    Inbal Ipenberg

    Mechanisms of signal-dependent activation of NF-kappaB precursor complexes

    • Lab of Claus Scheidereit, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Aaron Ciechanover, Technion - Israel Institute of Technology

    Publications

    • Ipenberg I, Guttmann-Raviv N, Khoury HP, Kupershmit I, Ayoub N (2013). Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. J. Biol. Chem. 288(21), 14681-14687
    • Yilmaz ZB, Kofahl B, Beaudette P, Baum K, Ipenberg I, Weih F, Wolf J, Dittmar G, Scheidereit C (2014). Quantitative dissection and modeling of the NF-kB p100-p105 module reveals interdependent precursor proteolysis. Cell Reports 9(5), 1756-1769
    • Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N (2014). PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U S A 111(7), E728-737

    Juliane Rademacher (geb. Brümmer)

    Rho GTPase signaling downstream of guidance receptors

    • Lab of Oliver Rocks, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Gera Neufeld, Technion - Israel Institute of Technology

    Undine Hill

    Epigenetic functions of the transcription factor CEBP/alpha

    • Lab of Achim Leutz, Max Delbrück Center for Molecular Medicine
    • Co-mentor: Amir Orian, Technion - Israel Institute of Technology

    Publications

    • Bledau AD, Schmidt K, Neumann K, Hill U, Ciotta G, Gupta A, Torres DC, Fu J, Kranz A, Stewart AF, Anastassiadis K (2014). The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation. Development 141(5), 1022-1035

    Shari Orlanski

    • Lab of Yehudit Bergman, Hebrew University of Jerusalem
    • Co-mentors: Klaus Rajewsky and Martin Janz, Max Delbrück Center for Molecular Medicine

    Publications

    • Penaloza C, Orlanski S, Ye Y, Entezari-Zaher T, Javdan M, Zakeri Z (2008). Cell death in mammalian development. Curr. Pharm. Des. 14(2), 184-196
    • Penaloza C, Estevez B, Orlanski S, Sikorska M, Walker R, Smith C, Smith B, Lockshin RA, Zakeri Z (2009). Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cells. FASEB J 23(6), 1869-1879
    • Orlanski S, Bergman Y (2012). Chapter 12: MicroRNAs in embryonic stem cells. In Appasani K (Ed.), Epigenomics: From chromatin biology to therapeutics (pp 163-178) Gene Expression Systems, Inc. ISBN: 9781139533997
    • Ludwig G, Nejman D, Hecht M, Orlanski S, Abu-Remaileh M, Yanuka O, Sandler O, Marx A, Roberts D, Benvenisty N, Bergman Y, Mendelsohn M, Cedar H (2014). Aberrant DNA methylation in ES cells. PloS One 9(5), e96090
    • Popowski M, Templeton TD, Lee BK, Rhee C, Li H, Miner C, Dekker JD, Orlanski S, Bergman Y, Iyer VR, Webb CF, Tucker H (2014). Bright/Arid3A acts as a barrier to somatic cell reprogramming through direct regulation of Oct4, Sox2, and Nanog. Stem Cell Reports 2(1), 26-35
    • Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y (2016). Tissue-specific DNA demethylation is required for proper B-cell differentiation and function. Proc Natl Acad Sci U S A 113(18), 5018-23

    Sylvia Zérath Gurevich

    Biology and proteomics of the small protein modifier, Rub1

    • Lab of Michael Glickman, Technion - Israel Institute of Technology
    • Co-mentors: Gunnar Dittmar and Thomas Sommer, Max Delbrück Center for Molecular Medicine

    Publications

    • Singh RK, Zérath S, Kleifeld O, Scheffner M, Glickman MH, Fushman D (2012). Recognition and cleavage of related to ubiquitin (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol. Cell. Proteomics 11(12), 1595-1611

    Contact

    Dr. Hanna Singer
    Max Delbrück Center for Molecular Medicine
    Robert-Rössle-Str 10
    13125 Berlin
    Germany

    Phone: +49 30 9406 4205
    Fax: +49 30 9406 2170
    signgene@mdc-berlin.de