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Post Doctoral Position In Quantitative Proteomics

Wissenschaftler / Postdoc

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) is one of the world’s leading biomedical research institutions. Max Delbrück, a Berlin native, was a Nobel laureate and one of the founders of molecular biology. At the MDC’s locations in Berlin-Buch and Mitte, researchers from some 60 countries analyze the human system – investigating the biological foundations of life from its most elementary building blocks to systems-wide mechanisms. By understanding what regulates or disrupts the dynamic equilibrium in a cell, an organ, or the entire body, we can prevent diseases, diagnose them earlier, and stop their progression with tailored therapies. Patients should benefit as soon as possible from basic research discoveries. The MDC therefore supports spin-off creation and participates in collaborative networks. It works in close partnership with Charité – Universitätsmedizin Berlin in the jointly run Experimental and Clinical Research Center (ECRC ), the Berlin Institute of Health (BIH) at Charité, and the German Center for Cardiovascular Research (DZHK). Founded in 1992, the MDC today employs 1,600 people and is funded 90 percent by the German federal government and 10 percent by the State of Berlin.

An ERC funded post-doctoral positions are available in the research group of Dr. Ilaria Piazza at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) in Berlin, Germany.

Ihre Aufgaben

The Piazza laboratory (Piazza Lab) uses mass spectrometry-based approaches to study protein conformational changes in cell and tissues integrating proteomics and metabolomics data with structural biology. The successful candidates will devise new proteomics methods to measure protein-metabolite and protein-drug interactions. You will work on an exciting project that aims to understand how metabolic alterations alter proteome dynamics, obtaining biological insights about protein allostery.

You will join a young and enthusiastic team of scientists working at the cutting edge of proteomics (Piazza Group). You will focus on the application of advanced proteomics analyses based on data-independent acquisition (DIA) mass spectrometry and apply relevant bioinformatics approaches. You will have access to state-of-the-art instrumentation and be involved in international cross-disciplinary collaborations. The successful candidate will take a strong lead in the experimental design and data interpretation collaborating with other team members.

Ihr Profil

Applicants should have a solid experimental or computational background, a strong publication record as primary author, and excellent communication skills in English.

The candidate should have:

  • A PhD in biochemistry, systems biology, molecular biology or equivalent.
  • A strong interest in proteomics, technology development and quantitative biology.
  • General knowledge of label free mass spectrometry-based proteomics techniques, experience in handling Orbitrap mass spectrometers such as Thermo HF-X or Exploris 480, and proteomics data analysis with R, python or shiny applications.
  • Bioinformatic analysis of proteomics data based on correlations, pathway enrichment, signature motif analysis, and machine learning for class discovery and pattern recognition.
  • Previous experience with work with human cancer cell lines or stem cells is a plus.
  • Programming skills with Python or R is a plus.
  • Ability to work independently and in teams. Excellent communication skills.

A strong interest in interdisciplinary research and integration of metabolomics and proteomics concepts are the requisite skills for this position, thus applicants wishing to integrate computational and experimental biology approaches are specifically encouraged to apply.

Ihre Benefits

  • International working environment with communication in English and German
  • Interesting career opportunities and a comprehensive range of qualification and further training opportunities
  • Compatibility of family and career certified by the berufundfamilie audit
  • Varied support for "New Berliners" (Welcome & Family Office)
  • Company health management with fitness center

You also benefit from:

  • A remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
  • Flexible working hours and childcare support
  • An idyllic green campus, which is easily accessible by bicycle, public transport or car

Weitere Informationen:

Beschäftigungsgruppe:


Team:


Bewerbungsfrist:
12. Dezember 2021


Arbeitsort:
MDC Berlin-Buch


Vergütung:
German TVÖD (Bund) E13 based on experience and qualification.


Beschäftigungsumfang:
Vollzeit


Gewünschter Eintrittstermin:
01. Januar 2022


Befristung:
befristet
The initial contract will be offered for 2 years with the possibility of extension.


Kontakt:
Ilaria Piazza
AG Piazza
ilaria.piazza@mdc-berlin.de


Chancengleichheit:
The MDC is committed to diversity and actively promotes equal opportunities for all employees regardless of their origin, religion, ideology, health impairment, age or sexual identity. We look forward to receiving applications from open-minded people who enjoy working in diverse teams. Applications from severely disabled persons will be given special consideration.


Bewerbung:
Please use our online portal and submit your application (including a cover letter, CV, references as well as relevant educational and degree certificates)


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