The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution
Autor/innen
- D.M. Taylor
- B.J. Aronow
- K. Tan
- K. Bernt
- N. Salomonis
- C.S. Greene
- A. Frolova
- S.E. Henrickson
- A. Wells
- L. Pei
- J.K. Jaiswal
- J. Whitsett
- K.E. Hamilton
- S.A. MacParland
- J. Kelsen
- R.O. Heuckeroth
- S.S. Potter
- L.A. Vella
- N.A. Terry
- L.R. Ghanem
- B.C. Kennedy
- I. Helbig
- K.E. Sullivan
- L. Castelo-Soccio
- A. Kreigstein
- F. Herse
- M.C. Nawijn
- G.H. Koppelman
- M. Haendel
- N.L. Harris
- J.L. Rokita
- Y. Zhang
- A. Regev
- O. Rozenblatt-Rosen
- J.E. Rood
- T.L Tickle
- R. Vento-Tormo
- S. Alimohamed
- M. Lek
- J.C. Mar
- K.M. Loomes
- D.M. Barrett
- P. Uapinyoying
- A.H. Beggs
- P.B. Agrawal
- Y.W. Chen
- A.B. Muir
- L.X. Garmire
- S.B. Snapper
- J. Nazarian
- S.H. Seeholzer
- H. Fazelinia
- L.N. Singh
- R.B. Faryabi
- P. Raman
- N. Dawany
- H.M. Xie
- B. Devkota
- S.J. Diskin
- S.A. Anderson
- E.F. Rappaport
- W. Peranteau
- K.A. Wikenheiser-Brokamp
- S. Teichmann
- D. Wallace
- T. Peng
- Y.Y. Ding
- M.S. Kim
- Y. Xing
- S.W. Kong
- C.G. Bönnemann
- K.D. Mandl
- P.S. White
Journal
- Developmental Cell
Quellenangabe
- Dev Cell 49 (1): 10-29
Zusammenfassung
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.