Pharmacological fMRI - challenges in analysing drug-induced single-event BOLD responses

Autor/innen

  • A. Pohlmann
  • H. Barjat
  • L.C. Tilling
  • M.F. James

Journal

  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Quellenangabe

  • Conf Proc IEEE Eng Med Biol Soc 2007: 3411-3416

Zusammenfassung

  • The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.


DOI

doi:10.1109/IEMBS.2007.4353064