RIF1 acts as a gatekeeper of B cell identity during late differentiation

Autor/innen

  • A. Rahjouei
  • E. Kabrani
  • M. Berruezo-Llacuna
  • R. Altwasser
  • V. Delgado-Benito
  • R. Pavri
  • M. Di Virgilio

Journal

  • bioRxiv

Quellenangabe

  • bioRxiv

Zusammenfassung

  • RIF1 is a multifunctional protein that promotes immunoglobulin (Ig) isotype diversification. Whether RIF1 plays additional roles in adaptive immunity is unknown. In this study, we showed that Rif1 expression is upregulated following mature B cell activation, while its deficiency skewed the transcriptional profile of activated B cells towards plasmablasts (PBs) and plasma cells (PCs). Additionally, RIF1 ablation resulted in increased PB formation ex vivo and enhanced terminal differentiation into PCs upon immunization. Therefore, RIF1 serves as a cell identity gatekeeper during late B cell differentiation, providing an additional layer of control in the establishment of humoral immunity.


DOI

doi:10.1101/2023.07.18.549543