RIF1 acts as a gatekeeper of B cell identity during late differentiation
Autor/innen
- A. Rahjouei
- E. Kabrani
- M. Berruezo-Llacuna
- R. Altwasser
- V. Delgado-Benito
- R. Pavri
- M. Di Virgilio
Journal
- bioRxiv
Quellenangabe
- bioRxiv
Zusammenfassung
RIF1 is a multifunctional protein that promotes immunoglobulin (Ig) isotype diversification. Whether RIF1 plays additional roles in adaptive immunity is unknown. In this study, we showed that Rif1 expression is upregulated following mature B cell activation, while its deficiency skewed the transcriptional profile of activated B cells towards plasmablasts (PBs) and plasma cells (PCs). Additionally, RIF1 ablation resulted in increased PB formation ex vivo and enhanced terminal differentiation into PCs upon immunization. Therefore, RIF1 serves as a cell identity gatekeeper during late B cell differentiation, providing an additional layer of control in the establishment of humoral immunity.