Woman reading in MDC library

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in Hum Gene Ther

Efficient non-viral T cell engineering by Sleeping Beauty minicircles diminishing DNA toxicity and miRNAs silencing the endogenous TCR

J. Clauss et al.
in Mol Cell Biol

Activation-dependent TRAF3 exon 8 alternative splicing is controlled by CELF2 and hnRNP C binding to an upstream intronic element

A.S. Schultz et al.
in eLife

Domain-swapped T cell receptors improve the safety of TCR gene therapy

M.T. Bethune et al.
in Immunity

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity

E. Kieback et al.
in Mol Ther

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells

A. Gogol-Döring et al.
in Mol Ther

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer

M. Bunse et al.
in Sci Transl Med

TCR-ligand k(off) rate correlates with the protective capacity of antigen-specific CD8(+) T cells for adoptive transfer

M. Nauerth et al.
in PLoS ONE

MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy

G. Dössinger et al.