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in Neuroendocrinology

Increased activity of the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO) with consecutive tryptophan depletion predicts death in patients with neuroendocrine neoplasia

R. Pschowski et al.
in eLife

Domain-swapped T cell receptors improve the safety of TCR gene therapy

M.T. Bethune et al.
in J Biol Chem

Inactivation and anion selectivity of volume-regulated VRAC channels depend on carboxy-terminal residues of the first extracellular loop

F. Ullrich et al.
in Mol Syst Biol

Pervasive isoform-specific translational regulation via alternative transcription start sites in mammals

X. Wang et al.
in Nat Commun

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination

K. Gödde et al.
in Immunity

Thymus-derived regulatory T cells are positively selected on natural self-antigen through cognate interactions of high functional avidity

E. Kieback et al.
in Nat Rev Mol Cell Biol

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

T.J. Jentsch
in J Biol Chem

KCNQ potassium channels modulate sensitivity of skin D-hair mechanoreceptors

S. Schütze et al.
in Pflugers Arch

VRAC: molecular identification as LRRC8 heteromers with differential functions

T.J. Jentsch et al.
in Mol Ther

Genome-wide profiling reveals remarkable parallels between insertion site selection properties of the MLV retrovirus and the piggyBac transposon in primary human CD4(+) T cells

A. Gogol-Döring et al.