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01. Oktober 2015 in Gastroenterology

T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice

C. Dargel
M. Bassani-Sternberg
J. Hasreiter
F. Zani
J.H. Bockmann
F. Thiele
F. Bohne
K. Wisskirchen
S. Wilde
M.F. Sprinzl
D.J. Schendel
A.M. Krackhardt
W. Uckert
D. Wohlleber
M. Schiemann
K. Stemmer
M. Heikenwälder
D.H. Busch
G. Richter
M. Mann
U. Protzer

01. Juni 2015 in BIOspektrum

Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs]

M. Leisegang
W. Uckert

15. April 2015 in Int J Cancer

Gene expression profiling of peripheral blood mononuclear cells during treatment with a gene-modified allogeneic tumor cell vaccine in advanced renal cell cancer: tumor-induced immunosuppression and a possible role for NF-κB

A. Flörcken
M. Grau
A. Wolf
A. Weilemann
J. Kopp
B. Dörken
T. Blankenstein
A. Pezzutto
P. Lenz
G. Lenz
J. Westermann

01. April 2015 in Curr Opin Immunol

Targeting cancer-specific mutations by T cell receptor gene therapy

T. Blankenstein
M. Leisegang
W. Uckert
H. Schreiber

01. April 2015 in Nat Biotechnol

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

M. Obenaus
C. Leitão
M. Leisegang
X. Chen
I. Gavvovidis
P. van der Bruggen
W. Uckert
D.J. Schendel
T. Blankenstein

23. März 2015 in PLoS ONE

Codon optimization of the human papillomavirus E7 oncogene induces a CD8(+) T cell response to a cryptic epitope not harbored by wild-type E7

F.K.M. Lorenz
S. Wilde
K. Voigt
E. Kieback
B. Mosetter
D.J. Schendel
W. Uckert

01. Februar 2015 in J Immunol

CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor

S. Ghorashian
P. Veliça
I. Chua
A. McNicol
B. Carpenter
A. Holler
E. Nicholson
M. Ahmadi
M. Zech
S. Xue
W. Uckert
E. Morris
R. Chakraverty
H.J. Stauss

15. Januar 2015 in J Immunol

IFN-γ regulates CD8(+) memory T cell differentiation and survival in response to weak, but not strong, TCR signals

D. Stoycheva
K. Deiser
L. Stärck
G. Nishanth
D. Schlüter
W. Uckert
T. Schüler

13. Dezember 2011 in Canc Cell

Oncogene-targeting T cells reject large tumors while oncogene inactivation selects escape variants in mouse models of cancer

K. Anders
C. Buschow
A. Herrmann
A. Milojkovic
C. Loddenkemper
T. Kammertoens
P. Daniel
H. Yu
J. Charo
T. Blankenstein

01. November 2011 in Eur J Immunol

Visualizing the dynamic of adoptively transferred T cells during the rejection of large established tumors

J. Charo
C. Perez
C. Buschow
A. Jukica
M. Czeh
T. Blankenstein