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in Gastroenterology

T cells engineered to express a T-cell receptor specific for glypican-3 recognize and kill hepatoma cells in vitro and in mice

  • C. Dargel
  • M. Bassani-Sternberg
  • J. Hasreiter
  • F. Zani
  • J.H. Bockmann
  • F. Thiele
  • F. Bohne
  • K. Wisskirchen
  • S. Wilde
  • M.F. Sprinzl
  • D.J. Schendel
  • A.M. Krackhardt
  • W. Uckert
  • D. Wohlleber
  • M. Schiemann
  • K. Stemmer
  • M. Heikenwälder
  • D.H. Busch
  • G. Richter
  • M. Mann
  • U. Protzer
in BIOspektrum

Designer T cells - New possibilities for immunotherapy of cancer [Designer-T-Zellen - neue Möglichkeiten für die Immuntherapie von Krebs]

  • M. Leisegang
  • W. Uckert
in Curr Opin Immunol

Targeting cancer-specific mutations by T cell receptor gene therapy

  • T. Blankenstein
  • M. Leisegang
  • W. Uckert
  • H. Schreiber
in Nat Biotechnol

Identification of human T-cell receptors with optimal affinity to cancer antigens using antigen-negative humanized mice

  • M. Obenaus
  • C. Leitão
  • M. Leisegang
  • X. Chen
  • I. Gavvovidis
  • P. van der Bruggen
  • W. Uckert
  • D.J. Schendel
  • T. Blankenstein
in PLoS ONE

Codon optimization of the human papillomavirus E7 oncogene induces a CD8(+) T cell response to a cryptic epitope not harbored by wild-type E7

  • F.K.M. Lorenz
  • S. Wilde
  • K. Voigt
  • E. Kieback
  • B. Mosetter
  • D.J. Schendel
  • W. Uckert
in J Immunol

CD8 T cell tolerance to a tumor-associated self-antigen is reversed by CD4 T cells engineered to express the same T cell receptor

  • S. Ghorashian
  • P. Veliça
  • I. Chua
  • A. McNicol
  • B. Carpenter
  • A. Holler
  • E. Nicholson
  • M. Ahmadi
  • M. Zech
  • S. Xue
  • W. Uckert
  • E. Morris
  • R. Chakraverty
  • H.J. Stauss
in J Immunol

IFN-γ regulates CD8(+) memory T cell differentiation and survival in response to weak, but not strong, TCR signals

  • D. Stoycheva
  • K. Deiser
  • L. Stärck
  • G. Nishanth
  • D. Schlüter
  • W. Uckert
  • T. Schüler
in Hum Gene Ther Clin Dev

HEK293-based production platform for γ-retroviral (SIN-) vectors: application for safe and efficient transfer of COL7A1 cDNA

  • K. Hennig
  • L. Raasch
  • C. Kolbe
  • S. Weidner
  • M. Leisegang
  • W. Uckert
  • M. Titeux
  • A. Hovnanian
  • K. Kuehlcke
  • R. Loew
in Mol Ther

RNAi-mediated TCR knockdown prevents autoimmunity in mice caused by mixed TCR dimers following TCR gene transfer

  • M. Bunse
  • G.M. Bendle
  • C. Linnemann
  • L. Bies
  • S. Schulz
  • T.N. Schumacher
  • W. Uckert
in Hum Gene Ther Methods

Manufacture of gene modified human T cells with a memory stem/ central memory phenotype

  • R. Gomez-Eerland
  • B. Nuijen
  • B. Heemskerk
  • N. van Rooij
  • J.H. van den Berg
  • J.H. Beijnen
  • W. Uckert
  • P. Kvistborg
  • T. Schumacher
  • J.B.A.G. Haanen
  • A. Jorritsma