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07. Januar 2021 in Cancers

Cold-shock domains - abundance, structure, properties, and nucleic-acid binding

U. Heinemann
Y. Roske

10. Dezember 2020 in J Med Chem

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement

Y. Mostinski
G.J.J.E. Heynen
M.P. López-Alberca
J. Paul
S. Miksche
S. Radetzki
D. Schaller
E. Shanina
C. Seyffarth
Y. Kolomeets
N. Ziebart
J. de Schryver
S. Oestreich
M. Neuenschwander
Y. Roske
U. Heinemann
C. Rademacher
A. Volkamer
J.P. von Kries
W. Birchmeier
M. Nazaré

24. November 2020 in Proc Natl Acad Sci U S A

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

M. Barone
M. Müller
S. Chiha
J. Ren
D. Albat
A. Soicke
S. Dohmen
M. Klein
J. Bruns
M. van Dinther
R. Opitz
P. Lindemann
M. Beerbaum
K. Motzny
Y. Roske
P. Schmieder
R. Volkmer
M. Nazaré
U. Heinemann
H. Oschkinat
P. Ten Dijke
H.G. Schmalz
R. Kühne

01. August 2020 in J Struct Biol

Crystal structure of Q4D6Q6, a conserved kinetoplastid-specific protein from Trypanosoma cruzi

E. Dias D'Andréa
Y. Roske
G.A.P. de Oliveira
N. Cremer
A. Diehl
P. Schmieder
U. Heinemann
H. Oschkinat
J. Ricardo Pires

05. Mai 2020 in Symmetry

Symmetry in nucleic-acid double helices

U. Heinemann
Y. Roske

05. März 2020 in Biochem Biophys Res Commun

Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae

O.P. Chouhan
Y. Roske
U. Heinemann
S. Biswas

03. Dezember 2019 in Structure

Common mode of remodeling AAA ATPases p97/CDC48 by their disassembling cofactors ASPL/PUX1

S. Banchenko
A. Arumughan
S. Petrović
D. Schwefel
E.E. Wanker
Y. Roske
U. Heinemann

29. November 2019 in Int J Mol Sci

Structural features of tight-junction proteins

U. Heinemann
A. Schuetz

06. November 2019 in ChemMedChem

Structure-based screening of tetrazolylhydrazide inhibitors versus KDM4 histone demethylases

P.H. Malecki
N. Rueger
M. Roatsch
O. Krylova
A. Link
M. Jung
U. Heinemann
M.S. Weiss

02. August 2019 in J Biol Chem

Time-resolved DNA release from an O-antigen specific Salmonella bacteriophage with a contractile tail

N.K. Broeker
Y. Roske
A. Valleriani
M.S. Stephan
D. Andres
J. Koetz
U. Heinemann
S. Barbirz