Wissenschaftliche Publikationen | Max Delbrück Center

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01. Dezember 2023 / Biomed Pharmacother

Discovery of tetrazolo-pyridazine-based small molecules as inhibitors of MACC1-driven cancer metastasis

S. Yan
P.C. Schöpe
J. Lewis
K. Putzker
U. Uhrig
E. Specker
J.P. von Kries
P. Lindemann
A. Omran
H.E. Sanchez-Ibarra
A. Unger
M.L. Zischinsky
B. Klebl
W. Walther
M. Nazaré
D. Kobelt
U. Stein

01. März 2023 / NAR Genom Bioinform

A computational map of the human-SARS-CoV-2 protein-RNA interactome predicted at single-nucleotide resolution

M. Horlacher
S. Oleshko
Y. Hu
M. Ghanbari
G. Cantini
P. Schinke
E.E. Vergara
F. Bittner
N.S Mueller
U. Ohler
L. Moyon
A. Marsico

23. September 2022 / Oncogene

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis

B. Kortüm
H. Radhakrishnan
F. Zincke
C. Sachse
S. Burock
U. Keilholz
M. Dahlmann
W. Walther
G. Dittmar
D. Kobelt
U. Stein

10. September 2022 / Nat Commun

Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes

R. Monti
P. Rautenstrauch
M. Ghanbari
A.R. James
M. Kirchler
U. Ohler
S. Konigorski
C. Lippert

01. September 2022 / Br J Cancer

Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker

F. Schmid
M. Dahlmann
H. Röhrich
D. Kobelt
J. Hoffmann
S. Burock
W. Walther
U. Stein

23. Juni 2022 / Methods Mol Biol

Capillary gel electrophoresis (CGE) for quality control of plasmid DNA in gene therapy: quality control of 20 years stored GMP-grade plasmid DNA

M. Schmeer
M. Schleef
R. Shankar
D. Kobelt
W. Walther

23. Juni 2022 / Methods Mol Biol

Claudin-targeted suicide gene therapy for claudin-overexpressing tumor cells by using modified clostridium perfringens enterotoxin (CPE)

L.S. Beier
J. Piontek
A. Piontek
J. Protze
D. Kobelt
W. Walther

23. Juni 2022 / Methods Mol Biol

A brief introduction to current cancer gene therapy

D. Kobelt
J. Pahle
W. Walther

09. Juni 2022 / Cancers

MACC1-induced collective migration is promoted by proliferation rather than single cell biomechanics

T. Hohmann
U. Hohmann
M. Dahlmann
D. Kobelt
U. Stein
F. Dehghani

01. April 2022 / Cancers

Elevated MACC1 expression in colorectal cancer is driven by chromosomal instability and is associated with molecular subtype and worse patient survival

V. Vuaroqueaux
A. Musch
D. Kobelt
T: Risch
P. Herrmann
S. Burock
A.L. Peille
M.L. Yaspo
H.H. Fiebig
U. Stein