Wissenschaftliche Publikationen

Structure of tetrameric forms of the serotonin-gated 5-HT3(A) receptor ion channel

B. Introini
W. Cui
X. Chu
Y. Zhang
A.C. Alves
L. Eckhardt-Strelau
S. Golusik
M. Tol
H. Vogel
S. Yuan
M. Kudryashev

02. April 2024 / Mol Syst Biol

AI-guided pipeline for protein-protein interaction drug discovery identifies an SARS-CoV-2 inhibitor

P. Trepte
C. Secker
J. Olivet
J. Blavier
S. Kostova
S.B. Maseko
I. Minia
E. Silva Ramos
P. Cassonnet
S. Golusik
M. Zenkner
S. Beetz
M.J. Liebich
N. Scharek
A. Schutz
M. Sperling
M. Lisurek
Y. Wang
K. Spirohn
T. Hao
M.A. Calderwood
D.E. Hill
M. Landthaler
S.G. Choi
J.C. Twizere
M. Vidal
E.E. Wanker

GIPC1 regulates MACC1-driven metastasis

F. Siegel
H. Schmidt
M. Juneja
J. Smith
P. Herrmann
D. Kobelt
K. Sharma
I. Fichtner
W. Walther
G. Dittmar
R. Volkmer
F.G. Rathjen
P.M. Schlag
U. Stein

Establishment and thorough characterization of xenograft (PDX) models derived from patients with pancreatic cancer for molecular analyses and chemosensitivity testing

D. Behrens
U. Pfohl
T. Conrad
M. Becker
B. Brzezicha
B. Büttner
S. Wagner
C. Hallas
R. Lawlor
V. Khazak
M. Linnebacher
T. Wartmann
I. Fichtner
J. Hoffmann
M. Dahlmann
W. Walther

Small molecule specifically inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

P. Jordan
A. Costa
E. Specker
O. Popp
A. Volkamer
R. Piske
T. Obrusnik
S. Kleissle
K. Stuke
A. Rex
M. Neuenschwander
J.P. von Kries
M. Nazare
P. Mertins
H. Kettenmann
S.A. Wolf

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasis

B. Kortüm
H. Radhakrishnan
F. Zincke
C. Sachse
S. Burock
U. Keilholz
M. Dahlmann
W. Walther
G. Dittmar
D. Kobelt
U. Stein

Calcium-binding protein S100P is a new target gene of MACC1, drives colorectal cancer metastasis and serves as a prognostic biomarker

F. Schmid
M. Dahlmann
H. Röhrich
D. Kobelt
J. Hoffmann
S. Burock
W. Walther
U. Stein

Core-clock genes regulate proliferation and invasion via a reciprocal interplay with MACC1 in colorectal cancer cells

A. Basti
D. Malhan
M. Dumbani
M. Dahlmann
U. Stein
A. Relógio

A molecularly characterized preclinical platform of subcutaneous renal cell carcinoma (RCC) patient-derived xenograft models to evaluate novel treatment strategies

D. Gürgen
M. Becker
M. Dahlmann
S. Flechsig
E. Schaeffeler
F.A. Büttner
C. Schmees
R. Bohnert
J. Bedke
M. Schwab
J.J. Wendler
M. Schostak
B. Jandrig
W. Walther
J. Hoffmann

MACC1-induced collective migration is promoted by proliferation rather than single cell biomechanics

T. Hohmann
U. Hohmann
M. Dahlmann
D. Kobelt
U. Stein
F. Dehghani