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in Neurobiol Dis

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles

  • D.L. Smith
  • R. Portier
  • B. Woodman
  • E. Hockly
  • A. Mahal
  • W.E. Klunk
  • X.J. Li
  • E.E. Wanker
  • K.D. Murray
  • G.P. Bates
in Hum Mol Genet

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

  • K. Sathasivam
  • B. Woodman
  • A. Mahal
  • F. Bertaux
  • E.E. Wanker
  • D.T. Shima
  • G.P. Bates
in Hum Mol Genet

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

  • S. Waelter
  • E. Scherzinger
  • R. Hasenbank
  • E. Nordhoff
  • R. Lurz
  • H. Goehler
  • C. Gauss
  • K. Sathasivam
  • G.P. Bates
  • H. Lehrach
  • E.E. Wanker
in Hum Mol Genet

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

  • A. Sittler
  • R. Lurz
  • G. Lueder
  • J. Priller
  • H. Lehrach
  • M.K. Hayer-Hartl
  • F.U. Hartl
  • E.E. Wanker
in Mol Biol Cell

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

  • S. Waelter
  • A. Boeddrich
  • R. Lurz
  • E. Scherzinger
  • G. Lueder
  • H. Lehrach
  • E.E. Wanker
in J Cell Biol

Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis

  • M. Hellström
  • H. Gerhardt
  • M. Kalén
  • X. Li
  • U. Eriksson
  • H. Wolburg
  • C. Betsholtz
in Cytogenet Genome Res

Assignment of the huntingtin (Hdh) gene, the huntingtin associated protein (Hap1) gene, and the huntingtin interacting protein (Hip1) gene to rat chromosomes 14, 10, and 12 by radiation hybrid mapping and fluorescent in situ hybridization

  • H. Zimdahl
  • C. Goesele
  • G. Luetjens
  • F. Gruetzner
  • T. Kreitler
  • K. Voss
  • E.E. Wanker
  • M. Knoblauch
in Genomics

Localization of the human HIP1 gene close to the elastin (ELN) locus on 7q11.23

  • N. Wedemeyer
  • R. Peoples
  • H. Himmelbauer
  • H. Lehrach
  • U. Francke
  • E.E. Wanker
in Cell

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

  • S.W. Davies
  • M. Turmaine
  • B.A. Cozens
  • M. DiFiglia
  • A.H. Sharp
  • C.A. Ross
  • E. Scherzinger
  • E.E. Wanker
  • L. Mangiarini
  • G.P. Bates
in Cell

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

  • E. Scherzinger
  • R. Lurz
  • M. Turmaine
  • L. Mangiarini
  • B. Hollenbach
  • R. Hasenbank
  • G.P. Bates
  • S.W. Davies
  • H. Lehrach
  • E.E. Wanker