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Wissenschaftliche Publikationen

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/ J Med Chem

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement

  • Y. Mostinski
  • G.J.J.E. Heynen
  • M.P. López-Alberca
  • J. Paul
  • S. Miksche
  • S. Radetzki
  • D. Schaller
  • E. Shanina
  • C. Seyffarth
  • Y. Kolomeets
  • N. Ziebart
  • J. de Schryver
  • S. Oestreich
  • M. Neuenschwander
  • Y. Roske
  • U. Heinemann
  • C. Rademacher
  • A. Volkamer
  • J.P. von Kries
  • W. Birchmeier
  • M. Nazaré
/ Canc Res

A small-molecule antagonist of the β-catenin/TCF4 interaction blocks the self-renewal of cancer stem cells and suppresses tumorigenesis

  • L. Fang
  • Q. Zhu
  • M. Neuenschwander
  • E. Specker
  • A. Wulf-Goldenberg
  • W.I. Weis
  • J.P. von Kries
  • W. Birchmeier
/ ChemMedChem

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo

  • S. Grosskopf
  • C. Eckert
  • C. Arkona
  • S. Radetzki
  • K. Böhm
  • U. Heinemann
  • G. Wolber
  • J.P. von Kries
  • W. Birchmeier
  • J. Rademann
/ Proc Natl Acad Sci U S A

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

  • K. Hellmuth
  • S. Grosskopf
  • C.T. Lum
  • M. Wuertele
  • N. Roeder
  • J.P. von Kries
  • M. Rosario
  • J. Rademann
  • W. Birchmeier
/ Nat Struct Biol

Hot spots in beta-catenin for interactions with LEF-1, conductin and APC

  • J.P. von Kries
  • G. Winbeck
  • C. Asbrand
  • T. Schwarz-Romond
  • N. Sochnikova
  • A. Dell'Oro
  • J. Behrens
  • W. Birchmeier
/ Nature

Functional interaction of beta-catenin with the transcription factor LEF-1

  • J. Behrens
  • J.P. von Kries
  • M. Kuehl
  • L. Bruhn
  • D. Wedlich
  • R. Grosschedl
  • W. Birchmeier