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in Development

Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning

I. Geudens et al.
in Cell Rep

53BP1 supports immunoglobulin class switch recombination independently of its DNA double-strand break end protection function

D. Sundaravinayagam et al.
in Mol Cell

R-loops enhance polycomb repression at a subset of developmental regulator genes

K. Skourti-Stathaki et al.
in Dev Cell

Spatiotemporal m(i)RNA architecture and 3' UTR regulation in the C. elegans germline

A. Diag et al.
in eLife

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

Z. Farsi et al.
in Sci Rep

Loss-of-function uORF mutations in human malignancies

J. Schulz et al.
in Mol Syst Biol

RNA polymerase II primes Polycomb-repressed developmental genes throughout terminal neuronal differentiation

C. Ferrai et al.
in Nat Commun

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

G. Kar et al.
in PLoS Biol

Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

M. Juneja et al.
in Nat Struct Mol Biol

Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells

M. Barbieri et al.