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21. Dezember 2020 in Nat Commun

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

J. Grinat
J. Heuberger
R. Vidal
N. Goveas
F. Kosel
A. Berenguer-Llergo
A. Kranz
A. Wulf-Goldenberg
D. Behrens
B. Melcher
S. Sauer
M. Vieth
E. Batlle
A. Stewart
W. Birchmeier

10. Dezember 2020 in J Med Chem

From pyrazolones to azaindoles: evolution of active-site SHP2 inhibitors based on scaffold hopping and bioisosteric replacement

Y. Mostinski
G.J.J.E. Heynen
M.P. López-Alberca
J. Paul
S. Miksche
S. Radetzki
D. Schaller
E. Shanina
C. Seyffarth
Y. Kolomeets
N. Ziebart
J. de Schryver
S. Oestreich
M. Neuenschwander
Y. Roske
U. Heinemann
C. Rademacher
A. Volkamer
J.P. von Kries
W. Birchmeier
M. Nazaré

01. Dezember 2020 in Hypertension

Proteomic analysis reveals upregulation of ACE2, the putative SARS-CoV-2 receptor in pressure- but not volume-overloaded human hearts

J. Stegbauer
M. Kraus
S. Nordmeyer
M. Kirchner
M. Ziehm
H. Dommisch
S. Kelle
M. Kelm
I. Baczko
U. Landmesser
C. Tschope
C. Knosalla
M. Falcke
M.P. Schapranow
V. Regitz-Zagrosek
P. Mertins
T. Kuehne

19. Juni 2020 in Nat Commun

Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice

F. Rudolph
C. Fink
J. Hüttemeister
M. Kirchner
M.H. Radke
J. Lopez Carballo
E. Wagner
T. Kohl
S.E. Lehnart
P. Mertins
M. Gotthardt

27. Mai 2020 in Cancers

Progression-dependent altered metabolism in osteosarcoma resulting in different nutrient source dependencies

R. Fritsche-Guenther
Y. Gloaguen
M. Kirchner
P. Mertins
P.U. Tunn
J.A. Kirwan

20. Februar 2020 in Nat Commun

Tracing tumorigenesis in a solid tumor model at single-cell resolution

S.D. Praktiknjo
B. Obermayer
Q. Zhu
L. Fang
H. Liu
H. Quinn
M. Stoeckius
C. Kocks
W. Birchmeier
N. Rajewsky

17. Februar 2020 in Nat Commun

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

A. Fendler
D. Bauer
J. Busch
K. Jung
A. Wulf-Goldenberg
S. Kunz
K. Song
A. Myszczyszyn
S. Elezkurtaj
B. Erguen
S. Jung
W. Chen
W. Birchmeier

10. Januar 2020 in Nat Commun

Cold-induced urticarial autoinflammatory syndrome related to factor XII activation

J. Scheffel
N.A. Mahnke
Z.L.M. Hofman
S.d. Maat
J. Wu
H. Bonnekoh
R.J. Pengelly
S. Ennis
J.W. Holloway
M. Kirchner
P. Mertins
M.K. Church
M. Maurer
C. Maas
K. Krause

01. Dezember 2019 in Brain

Decreased microglial Wnt/β-catenin signalling drives microglial pro-inflammatory activation in the developing brain

25. Oktober 2019 in Front Immunol

SHP-2 in lymphocytes' cytokine and inhibitory receptor signaling

C. Niogret
W. Birchmeier
G. Guarda