The MDC Mission

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) carries out basic biomedical research with the aim of understanding the molecular basis of health and disease, and translating these findings as quickly as possible into clinical application. The research involves the diagnosis and treatment of diseases, as well as their prevention.

Research Highlights

Insulin-sensitive fat leads to obesity

SORLA is a protein that influences metabolism in adipose tissue. If there is too much of the molecule, fat cells become overly sensitive to insulin and break down less fat. This new link between SORLA and increases in body weight was discovered by MDC researchers. SORLA was previously known for its role in defending the brain against Alzheimer’s disease.


Personalized medicine: T cells fight cancer

In cancer, one of the body’s cells stops playing by the rules that govern the cell cycle and divides uncontrollably. This is often due to mutations that lead to errors in the mechanisms that control cell division. Several teams of scientists at the MDC and the Charité are working on a T-cell therapy that specifically […]


Further research highlights


Successful recycling: Protein quality control in the cell

A team led by MDC researcher Annika Weber has pinpointed the efficient mechanism used by cells to label faulty proteins. The findings, which provide important insights into the functioning of protein quality control in the cell, have now been published in the journal Molecular Cell. Proteins perform a wide range of tasks within cells. For […]


Sascha Sauer is new head of MDC’s Genomics technology platform

Dr. Sascha Sauer has been at the helm of the scientific Genomics platform at the Berlin Institute for Medical Systems Biology (BIMSB) since August 2016. Among other initiatives, Sauer plans to further develop methods for single-cell analysis and make them available for collaborative projects, as well as overseeing various independent research projects, including in the […]


Microglia development follows a stepwise program to regulate brain homeostasis

MDC researcher Michael Sieweke joined forces with two research teams from the Weizmann Institute to publish a new study, which is pointing to the central role of transcription factor MafB on the final maturation steps of microglia.


Further news on MDC Insights