Building Networks – Interdisciplinary Kickoff to develop the Helmholtz Institute for Translational AngioCardioScience (HI-TAC)

Wednesday, March 30

14:00-14:10 Thomas Sommer & Heike Graßmann (MDC) – Welcome to MDC

14:10-14:20 Norbert Hübner (MDC) – Strategic direction of the MDC (POF IV)

14:20-14:30 Hellmut Augustin (MedMa, UHEI) – The vision of the Helmholtz Institute for Translational AngioCardioScience (HI-TAC)

14:30-15:30 Session I: Multiomics meets AngioCardioScience

Laleh Haghverdi (MDC) –Trustworthy inference of secondary quantities (e.g. cell state velocities, cell type labels, pseudotime) from single-cell omics data
Ashley Sanders (MDC) – Somatic cell mutations and their consequences by single-cell sequencing
Fabian Coscia (MDC) – Histopathology meets single cell proteomics for precision medicine
Daniela Panáková & Jan Philipp Junker (MDC) – Cellular drivers of injury response and regeneration in the adult zebrafish heart
Julio Saez-Rodrigues (MedHD, UHEI) – Spatial multi-omic map of human myocardial infarction

15:30-16:00 Coffee

16:00-17:30 Session II: Recent developments in AngioScience

Annette Hammes (MDC) –The role of Piezo2 in vascularization
Philipp Reiners-Koch (MedMa, UHEI) – Hepatic angiodiversity controls organ function and disease
Armin Rehm (MDC) – Lymphoma and angiogenesis: An integrative view on lymph node microarchitecture, immune response and clinical disease course
Mahak Singhal,(MedMa, UHEI) – Adaptation of vascular homeostasis to pathological challenge
Jörg Heineke (MedMa, UHEI) – Endothelial cells as crucial regulators of organ fibrosis
Daniel Dürschmied (MedMA, UHEI) – Blood platelets as a key regulator of inflammatory processes
Thomas Blankenstein (MDC) – The tumor vasculature as target of T cells

17:30-18:30 Session III: Berlin Cooperating Partners
Axel Pries (Charité – Universitätsmedizin Berlin) &
Christopher Baum (Berlin Institute of Health at Charité (BIH)) – Introduction
Ulf Landmesser (Charité) – Clinical research programs in vascular and interventional medicine
Michael Potente (BIH) – Metabolic decisions in vascular development and disease
Claudia Langenberg (BIH) – Plasma proteomics for target discovery and disease prediction
Burkert Pieske (Charité) – Heart Failure with Preserved Ejection Fraction – Mechanistic Understanding for stratified therapies: the New CRC 1470
Volkmar Falk (Charité) – The future heart center - DHZC

18:30 Get together

Thursday, March 31

09.00-09:30 Coffee

09:30-10:00 Welcome & Campus Tour

10:00-10:30 Session IV: MDC Infrastructure

Jutta Steinkötter (MDC) – Scientific technology platforms at MDC
Michaela Herzig (MDC) – Talent management at MDC

10:30-12:00 Session V: Recent developments in CardioScience

Johannes Backs (MedHD, UHEI) – HDACs in heart diseases: From mechanisms to therapies
Constanze Schmidt (MedHD, UHEI) – Atrial arrhythmopathy - From underlying molecular mechanisms to new therapeutic approaches
Chi-Chung Wu (MedMA, UHEI): Regulatory mechanisms of mammalian cardiomyocyte polyploidy
Gergana Dobreva (MedMa, UHEI) – Genetic and epigenetic regulation of cardiovascular development and disease
Maarten van den Hoogenhof (MedHD, UHEI) – CAMK2D underlies cardiac dysfunction in RBM20 cardiomyopathy
Arica Beisaw (MedHD, UHEI) – Intercellular communication in zebrafish cardiomyocyte regeneration
Norbert Frey (MedHD, UHEI) – Vision for Cardiovascular Medicine 2030 at Heidelberg University

12:00-12:30 Coffee & Snacks

12:30-13:20 Session VI: Cardiometabolic science & imaging

Mirko Völkers (MedHD, UHEI) – RNA metabolism in diseased cardiomyocytes
Gabriele Schiattarella (MDC) – Molecular underpinnings of cardiometabolic HFpEF
Gary Lewin (MDC) – Hypoxia and metabolism in naked mole-rats
Thoralf Niendorf (MDC) – Cardiovascular MRI

13:20 Concluding remarks

Organizers