News

Titin is the largest protein in the human body which takes on a central role in muscle fibers. A DZHK team now reports in „Science Translational Medicine“ how mutations in the titin gene can cause a disease of the heart muscle, dilated cardiomyopathy.

Daniela Panáková is studying a signaling pathway that is of critical importance for the heart muscle and congenital heart defects. The German Centre for Cardiovascular Research (DZHK) has now awarded her a grant of €80,000 to support this research.

As physician-scientist, Dr. Gabriele G. Schiattarella seeks to gain a detailed understanding of the most common cause of death in the Western world: cardiovascular diseases. The MDC and Charité are delighted to welcome him as a new research group leader at the Buch campus from November 1, 2020.

An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative.

Researchers from three continents have produced a first extensive draft of a cell atlas of the human heart to understand how this vital organ functions and to shed light on what goes wrong in cardiovascular disease. As the team reports in Nature, it reveals a huge cellular and molecular diversity.

The cellular biologist Thomas Sommer, who is the interim Scientific Director of the MDC, is celebrating his 60th birthday on May 23. We congratulate him on this milestone.

A heart seems to be pure physics: valves open and close, blood flows, electrical impulses control the heartbeat. A German-British research team is now looking at it in a different way. It will break down the heart into its smallest components - the cells - and unlock their secrets. The project is now being funded with 2.5 million euros for three years.

The fatty acid propionate helps defend against the effects of high blood pressure, including atherosclerosis and heart tissue remodeling, a study on mice has found. Gut bacteria produce the substance – which calms the immune cells that drive up blood pressure – from natural dietary fiber.

Heart muscle cells fuse together during cardiac development and repair processes.

Common salt reduces the number of certain lactic acid bacteria in the gut of mice and humans according to a study published in Nature by Berlin’s Max Delbrück Center and Charité. This has an impact on immune cells which are partly responsible for autoimmune diseases and hypertension. Probiotics ameliorate the symptoms of disease in mice.