News Search Search Category Topic Type Search Sort by RelevanceFrom A-ZAuthored onDate/Time RangeRelease date Order AscDesc Press release (4) Science (5) Alumni (10) Animal Research (61) Art (9) (-) Basic Research (8) Best Scientific Images Contest (1) BIH (25) BIMSB (42) Biochemistry & Proteomics (9) Campus (1) Campus Buch (16) Campus Life (43) Cancer (46) Cardiovascular Research (49) Career (22) Cartoon (4) Cell Biology (26) Charité (21) Clinical Research (25) Communication (28) Computational Biology (17) Construction (10) CultureCalendar (1) Developmental Biology (13) Disease-related Research (75) ECRC (19) Epidemiology (6) ERC (13) EU-Life (7) FMP (7) Gene Engineering (3) Gene Expression Regulation & RNA Biology (26) Genetics & Genomics (43) Green Campus (5) Helmholtz (7) History (17) Imaging (18) Immunology (23) Institute (9) Invitation (3) LabHacks (9) Labor trifft Lehrer (5) Life Science Learning Lab (3) LifeTime (5) Long Night of Science (14) MDC-Forschung (15) Metabolism (11) MustRead (4) NAKO (7) Neuroscience (43) Open Access (4) Personalia (75) Pharmacology (1) PhD Students (16) Physiology (3) Portrait (4) Postdocs (7) Prizes & Awards (39) Refugees (1) Research Highlight (156) Responsible Research (1) science policy (2) Signal Transduction (2) Single-cell analysis (10) Society of Friends of the MDC (6) Stem Cell Biology (30) Structural Biology & Biophysics (12) Support for Scientists (5) Systems Biology (35) Teachers & Pupils (15) Teaching (1) Technology Platforms (23) Technology Transfer (10) Trainees (3) We at the MDC (4) Women in Science (12) Work and Family (4) Zeitzeugen (2) News (4) Press Release (4) 8 Results: Active Filter: Basic Research Sort: Result score Newest to oldest Oldest to newest Science November 27, 2018 By Dr. Martin Ballaschk The immune system as a sculptor Breaks in our DNA are usually undesirable – unless the immune system is at work. A new study conducted by Michela Di Virgilio’s research group and published in „Molecular Cell“ shows how creatively and yet precisely cells can break up their genetic material and piece it back together. Press Release No. 19 August 13, 2018 Berlin Joining forces for immune research In a new initiative, 23 groups from five Helmholtz Centers are joining forces to address some of the most complex problems in today's immunology in ways that can only be explored in collaboration. Press Release No. 10 April 18, 2018 Berlin Keeping the excitement under control James Poulet's lab listens to the activity of networks of single sensory neurons in the brain and discovered how a single signal from one cell manages to attract attention. Science December 04, 2017 A long and winding road Why does it take so long for new therapies to emerge from basic research? This is a question that researchers at the MDC and beyond encounter frequently. For us it was also the starting point for a film – and food for thought about the value of basic research. Science April 26, 2017 The search for the VRAC – three years later Prof. Thomas J. Jentsch knows: Results from basic research in biology sometimes can quickly become relevant for medicine. He tells us how this happened with one of his subjects of research. Science September 16, 2016 Protein quality control in the cell: Waste removal more efficient than expected Proteins perform so many vital tasks that without them, our bodies wouldn't function. In producing these molecules cells make a remarkable number of mistakes: about one third of all newly synthesized proteins are defective. A failure to recognize and eliminate them can lead to severe diseases. A team led by Prof. Thomas Sommer at the MDC has now gained new insights into the complex process of protein quality control in the cell. Press Release No. 31 August 26, 2016 Berlin Successful recycling: Protein quality control in the cell Proteins perform a wide range of tasks within cells. For everything to run smoothly, the cell must... Press Release No. 27 November 04, 2015 Berlin Uptake mechanisms of cytostatics discovered How does a cytostatic like cisplatin or carboplatin actually get into the cell? Scientists at the MaxDelbrück Center for Molecular Medicine in the Helmholtz Association (MDC) and the Leibniz-Institut für Molekulare Pharmakologie (FMP) in Berlin, in cooperation with a Dutch group, have now succeeded in showing that the volume-regulated anion channel VRAC is 50 % responsible for active substance uptake. If one of the VRAC subunits LRRC8A or LRRC8D is down-regulated, cells take up considerably less of the anti-cancer drug. In addition to this finding, programmed cell death or apoptosis is also significantly disturbed when LRRC8A is missing. The researchers have thus identified a potential cause for therapy resistance.