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Press release May 23, 2006

New Insights into the Building of the Heart Muscle

The heart is the first functioning organ in the developing mouse embryo. As the heart contracts with each heartbeat, it pumps blood through the body.

Science May 22, 2006

M-line deficient titin causes cardiac lethality through impaired maturation of the sarcomere

Titin is a giant muscle protein that forms a continuous filament system in both skeletal and cardiac muscle. It is composed of different functional units that enable titin to integrate...

Press release May 12, 2006

12 Million Euros from the European Commission for “RUBICON”

RUBICON Partner Institutions: 1: Karolinska Institutet , Sweden 2: The Netherlands Cancer Institute, Netherlands 3: University Medical Center Utrecht, Netherlands 4: MRC Human Genetics Unit, United Kingdom 5: University of...

Science May 11, 2006

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis

Arginine/lysine-rich motifs typically function as targeting signals for the translocation of proteins to the nucleus. In a new study, Annett Boeddrich (laboratory of Prof. Erich Wanker), Sebastian Gaumer, and colleagues...

Science May 11, 2006

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

A specialized quality control system samples the endoplasmic reticulum (ER) for proteins that deviate from their native conformation. Eventually, these polypeptides are relegated into the cytoplasm for degradation by the...

Science Apr 21, 2006

A structural role for ATP in the formation and stability of the human origin recognition complex

In the yeast S. cerevisiae , origins of DNA replication are defined by the recruitment of the multisubunit origin recognition complex (ORC). This interaction is sequence specific and ATP dependent...

Science Apr 18, 2006

Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biochemical and ischemic stress

The apoptosis-repressor-with-CARD (ARC) is a recently discovered anti-apoptotic factor with a highly specific expression pattern in striated muscle and neurons. ARC is a master regulator of cardiac death signaling, as...

Science Apr 10, 2006

Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1

Transposable elements (transposons) are segments of DNA with the ability to move from one location into another within genomes. These “jumping genes” can be considered molecular parasites that use the...

Press release Apr 07, 2006

Where’s the Starting Point?

In yeast, researchers know the origin of DNA replication. A complex made up of several proteins binds to certain regions of the DNA, depending on the presence of the molecule...

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Jutta.Kramm@mdc-berlin.de

+49 30 9406-2140

Jutta Kramm

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+49 30 9406-2121

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Deputy head, Events

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+49 30 9406-2120

Vera Glaßer

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