Prof. Dr. Michael Bader

                  

  

Cardiovascular Hormones

Max Delbrück Center for Molecular Medicine (MDC)

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Research interest:

The group is interested in the molecular biology and function of hormone systems involved in cardiovascular regulation, such as angiotensin, bradykinin, natriuretic peptides, and serotonin. Furthermore, the effects of these hormones in the central nervous system are a major subject of research.

Besides the cloning and characterization of genes for the components of these systems, the physiological functions of the hormones are analyzed by the production and phenotypical analysis of transgenic and gene-targeted animal models.

Methods:

Transgenic rat and knockout mouse technology

Cardiovascular phenotyping

Embryonic stem cells incl. in vitro differentiation

Selected publications

Alenina N; Kikic D; Todiras M; Mosienko V; Qadri F; Plehm R; Boye P; Vilianovitch L; Sohr R; Tenner K; Hoertnagl H; Bader M (2009)

Growth retardation and altered autonomic control in mice lacking brain serotonin

PNAS 106 (25): 10332-10337

Shmidt T, Hampich F, Ridders M, Schultrich S, Hans VH, Tenner K, Vilianovich L, Qadri F, Alenina N, Hartmann E, Köhler M, Bader M. (2007)

Normal brain development in importin-alpha5 deficient-mice.

 Nat Cell Biol. Dec;9(12):1337-8

Tenner K, Walther D, Bader M. (2007)

Influence of human tryptophan hydroxylase 2 N- and C-terminus on enzymatic activity and oligomerization.

J Neurochem. Sep;102(6):1887-94

Langenickel TH, Buttgereit J, Pagel-Langenickel I, Lindner M, Monti J, Beuerlein K, Al-Saadi N, Plehm R, Popova E, Tank J, Dietz R, Willenbrock R, Bader M. (2006)

Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B.

PNAS. Mar 21;103(12):4735-40

Walther D, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M. (2003)

Synthesis of serotonin by a second tryptophan hydroxylase isoform.

Science. 299: 76

Walther DJ, Peter JU, Winter S, Höltje M, Paulmann N, Grohmann M, Vowinckel J, Alamo-Bethencourt V, Wilhelm CS, Ahnert-Hilger G, Bader M. (2003)

Serotonylation of small GTPases is a signal transduction pathway that triggers platelet -granule release.

Cell. 115: 851-862.