Lab coats

Christian Rosenmund

Charite Neurowissenschafltiches Forschungszentrum / Charité Campus Mitte

christian.rosenmund (at) charite.de

more info see: www.rosenmundlab.de

Research interest of the Rosenmund lab:

1. Molecular mechanism of synaptic communication.

2. The Pathophysiology of mental retardation involving changes in synapse formation and -function.

Techniques we employ:

We use genetics, molecular biology, light and ultrastructural morphology, imaging & electrophysiology.

Professional experience

scince 2009 Faculty Position NeuroCure, Professor of Neurobiology, Charité -Universitätsmedizin Berlin

2003-2008 Associate Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), Baylor College of Medicine (BCM), Houston, TX USA

2005-present Associate Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), Baylor College of Medicine (BCM), Houston, TX USA

Director, Mouse Synaptic Plasticity Core, Mental Retardation Research Center at Baylor College of Medicine, Houston, TX

2005-present Faculty, Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX

2008-present Full Professor, Department of Molecular and Human Genetics and Department of Neuroscience (joint primary appointment), Baylor College of Medicine (BCM), Houston, TX USA

1999-2004 Lecturer in Physiology, Georg-Augusta Universitat Göttingen, Germany

1998-2003 Principal Investigator and Heisenberg Fellow, Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

Key publications of the last years:

Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. (2010) Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature 468(7321):263-9.

Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C. (2010) Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity. Nat Struct Mol Biol.;17(5):568-75.

Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC. (2010) Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol. 17(3):280-8.

Xue M, Lin YQ, Pan H, Reim K, Deng H, Bellen HJ, Rosenmund C (2010).Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron; 64(3):367-80.

Xue M, Rosenmund C (2009). The headache of a hyperactive calcium channel. Neuron 61(5):653-4.

Chaudhry C, Weston MC, Schuck P, Rosenmund C, Mayer ML (2009). Stability of ligandbinding domain dimer assembly controls kainate receptor desensitization. EMBO J. 28(10):1518-30.

Xue, M., Lin, YQ, Pan, H,., Reim, K., Deng, H., Bellen, HJ, Rosenmund, C. (2009). Tilting the balance of facilitatory and inhibitorfunctions of mammalian and Drosophila complexins orchestrates synaptic vesicle exocytosis. Neuron 12, 367-380.

Rizo, J. and Rosenmund, C. (2008) Synaptic vesicle fusion.  Review.  Nat. Struct. Mol. Biol. Jul;15(7):665-74.

 Chao, H.T., Zoghbi, H. and Rosenmund, C. (2007) MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron 4;56(1):58-65.

Wojcik, S.M., Rhee, J.S., Herzog, E., Sigler, A., Jahn, R., Takamori, S., Brose, N. and Rosenmund, C. (2004) An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size.  PNAS 101:7158-63.