Press Releases

MDC researchers have developed a new approach to CAR T-cell therapy. The team has shown in Nature Communications that the procedure is very effective, especially when it comes to fighting follicular lymphomas and chronic lymphocytic leukemia, the most common type of blood cancer in adults.

On January 1, 2021, the Berlin Institute of Health (BIH ) will become the translational research unit of Charité – Universitätsmedizin Berlin and will then form – alongside the hospital and the medical faculty – Charité’s third pillar.

Until recently, it was unclear how and why cancer cells adapt to their environment. A team led by Dr. Gaetano Gargiulo at MDC has now developed a technology that can be used to observe the molecular processes in living cells. The researchers present their results in the journal Cancer Discovery.

An international research team recently created the first atlas of the human heart. Now the scientists want to add a new dimension to the project: diversity. They are being supported by an additional Seed Networks grant from the Chan Zuckerberg Initiative.

A large grant under the NIH’s 4D Nucleome Program supports MDC scientist Ana Pombo’s work as a member of a multi-team consortium led by UC San Diego in the U.S. The team will investigate how DNA organizes inside cell nuclei and functions in space and time.

Female moles not only have ovarian, but also testicular tissue that produces male sex hormones – which lets them diverge from the categorization into two sexes. A team led by Berlin researchers Stefan Mundlos and Darío Lupiáñez describes in Science which genetic modifications contribute to this singular development.

A new algorithmic approach reveals individual tumors continue to evolve and remodel their genomes, and this occurs across a broad range of tumor types. Identifying changes that benefit tumors and help them metastasize could help with future treatments. Results are published in Nature.

The Berlin biotech start-up T-knife, a spin-off from the MDC together with Charité, has secured investments totaling €66 million. Four venture capital funds committed to the financing in early August. T-knife develops new cancer treatments using modified immune system T cells.

Apolipoprotein E4 is considered the most important genetic risk factor for Alzheimer’s disease. A group of researchers, led by MDC scientist Thomas Willnow, has now discovered how ApoE4 can damage the brain.

Setting out to identify all proteins that make up the sarcomere, the basic contractile unit of muscle cells, resulted in an unexpected revelation, providing experimental evidence that helps explain a fundamental mystery about how muscles work. The research was published in Nature Communications.