Press Releases

Theoretical physicists from Berlin teamed up with experimental physicists from Munich to determine the precise mechanics involved in cell motility. The findings were published in the journal Proceedings of the National Academy of Sciences (PNAS).

On January 1, 2021, the Berlin Institute of Health (BIH ) will become the translational research unit of Charité – Universitätsmedizin Berlin and will then form – alongside the hospital and the medical faculty – Charité’s third pillar.

Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body.

The Berlin biotech start-up T-knife, a spin-off from the MDC together with Charité, has secured investments totaling €66 million. Four venture capital funds committed to the financing in early August. T-knife develops new cancer treatments using modified immune system T cells.

A severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition. This is reported in Cell by experts of the nationwide deCOI research network, including colleagues at the MDC.

Setting out to identify all proteins that make up the sarcomere, the basic contractile unit of muscle cells, resulted in an unexpected revelation, providing experimental evidence that helps explain a fundamental mystery about how muscles work. The research was published in Nature Communications.

After more than 40 years, several teams at the MDC and ECRC have now made a breakthrough discovery with the help of two animal models: they have proven that an altered gene encoding the enzyme PDE3A causes an inherited form of high blood pressure. This could lead to new concepts for the treatment of hypertension.

Researchers at the ECRC have successfully used RNA molecules to treat a dangerous pregnancy disorder called preeclampsia. They were able to alleviate common symptoms of the disorder, like maternal high blood pressure and fetal undernutrition, with virtually no side effects.

A protein in the cell envelope influences the rate of fatty acid uptake in cells. This is reported by MDC researchers in the journal PNAS. This process also appears to be altered in overweight people.

Research groups from Charité – Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine (MDC) are joining forces with other Berlin-based partners. Pooling their experience and outstanding expertise in the field of mass spectrometry, they will form a new ‘Forschungskern’ or ‘research core’.