MDC Lab Coats

Why Y2H?

Why Y2H?

  • Y2H is powerful: many PPIs, highly relevant for physiology and pathology, have been identified using Y2H.

  • Y2H is fast, efficient, low-cost, high-throughput.

  • Y2H is flexible: it allows the generation of comprehensive PPI networks as well as small, focused networks for selected targets.

  • Y2H is sensitive: it permits detection of low-affinity interactions.

  • Y2H is variable: several subtypes permit detection of membrane PPIs, phosphorylation dependent PPIs, interaction between 3 proteins (MYTH-, CYTO-Y2H; Y3H etc.).

  • Y2H is a complementary method to affinity chromatography-based methods.

Y2H - how does it work?

Please contact us for further information or if you are interested in a screening.