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The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance

Authors

  • N. Royla
  • S. Kempa

Journal

  • Molecular & Cellular Oncology

Citation

  • Mol Cell Oncol 4 (4): e1338209

Abstract

  • Our recent study shows that the translation of MYC mRNA (mRNA) is controlled by its 3' untranslated region (UTR) in a process that depends on the availability of glutamine and levels of cellular nucleotides. Metabolic feedback protects cells from a lethal glutamine addiction and may compromise metabolic targeting of glutamine metabolism.


DOI

doi:10.1080/23723556.2017.1338209