Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories


  • N. Plath
  • O. Ohana
  • B. Dammermann
  • M.L. Errington
  • D. Schmitz
  • C. Gross
  • X. Mao
  • A. Engelsberg
  • C. Mahlke
  • H. Welzl
  • U. Kobalz
  • A. Stawrakakis
  • E. Fernandez
  • R. Waltereit
  • A. Bick-Sander
  • E. Therstappen
  • S.F. Cooke
  • V. Blanquet
  • W. Wurst
  • B. Salmen
  • M.R. Boesl
  • H.P. Lipp
  • S.G.N. Grant
  • T.V.P. Bliss
  • D.P. Wolfer
  • D. Kuhl


  • Neuron


  • Neuron 52 (3): 437-444


  • Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.