ATACing single cells with phages
Authors
- P. Maschmeyer
- S. Haas
Journal
- Molecular Cell
Citation
- Mol Cell 82 (2): 234-236
Abstract
Fiskin et al. (2021) developed a "multi-omics" approach that integrates phage-displayed single-domain antibodies ("nanobodies") with the assay for transposase-accessible chromatin (PHAGE-ATAC) to simultaneously determine protein expression, chromatin accessibility, and mitochondrial DNA mutations (for clonal tracing) in single cells.