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Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina

Authors

  • S. Faissner
  • F. Graz
  • S. Reinehr
  • L. Petrikowski
  • S. Haupeltshofer
  • U. Ceylan
  • G. Stute
  • S. Winklmeier
  • F. Pache
  • F. Paul
  • K. Ruprecht
  • E. Meinl
  • H.B. Dick
  • R. Gold
  • I. Kleiter
  • S.C. Joachim

Journal

  • Journal of Neuroimmunology

Citation

  • J Neuroimmunol 342: 577194

Abstract

  • Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or histological alterations in the retina.


DOI

doi:10.1016/j.jneuroim.2020.577194