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BiP binding keeps ATF6 at bay

Authors

  • T. Sommer
  • E. Jarosch

Journal

  • Developmental Cell

Citation

  • Dev Cell 3 (1): 1-2

Abstract

  • A study by Shen et al. in this issue of Developmental Cell shows that transport to the Golgi complex and subsequent proteolytic activation of the stress-regulated transcription factor ATF6 is initiated by the dissociation of the ER chaperone BiP from ATF6. This demonstrates that BiP is a key element in sensing the folding capacity within the ER and provides mechanistic insights on how the activation of membrane-bound transcription factors can be regulated.


DOI

doi:10.1016/S1534-5807(02)00210-1