BiP binding keeps ATF6 at bay
Authors
- T. Sommer
- E. Jarosch
Journal
- Developmental Cell
Citation
- Dev Cell 3 (1): 1-2
Abstract
A study by Shen et al. in this issue of Developmental Cell shows that transport to the Golgi complex and subsequent proteolytic activation of the stress-regulated transcription factor ATF6 is initiated by the dissociation of the ER chaperone BiP from ATF6. This demonstrates that BiP is a key element in sensing the folding capacity within the ER and provides mechanistic insights on how the activation of membrane-bound transcription factors can be regulated.