Brain serotonin critically contributes to the biological effects of electroconvulsive seizures


  • G. Kronenberg
  • M. Petermann
  • C. Dormann
  • M. Bader
  • P. Gass
  • R. Hellweg
  • F. Klempin


  • European Archives of Psychiatry and Clinical Neuroscience


  • Eur Arch Psychiatry Clin Neurosci 268 (8): 861-864


  • Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2(-/-) mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2(-/-) mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.