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cag+ Helicobacter pylori induces homotypic aggregation of macrophage-like cells by up-regulation and recruitment of intracellular adhesion molecule 1 to the cell surface

Authors

  • S. Moese
  • M. Selbach
  • T.F. Meyer
  • S. Backert

Journal

  • Infection and Immunity

Citation

  • Infect Immun 70 (8): 4687-4691

Abstract

  • Infection with cag+ but not cag-negative Helicobacter pylori leads to the formation of large homotypic aggregates of macrophage-like cells. Intracellular adhesion molecule 1 is up-regulated and recruited to the cell surface of infected cells and mediates the aggregation via lymphocyte function-associated molecule 1. This signaling may regulate cell-cell interactions and inflammatory responses.


DOI

doi:10.1128/IAI.70.8.4687-4691.2002