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Circulating endocannabinoid concentrations during orthostatic stress

Authors

  • C. Schroeder
  • S. Batkai
  • S. Engeli
  • J. Tank
  • A. Diedrich
  • F.C. Luft
  • J. Jordan

Journal

  • Clinical Autonomic Research

Citation

  • Clin Auton Res 19 (6): 343-346

Abstract

  • BACKGROUND: In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition. MATERIALS AND METHODS: We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope. RESULTS: With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged. CONCLUSIONS: In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.


DOI

doi:10.1007/s10286-009-0026-1