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Circulating HLA-G and its association with cardiovascular markers in pregnancy

Authors

  • T. Lekva
  • D.P. Jacobsen
  • M. Sugulle
  • K. Moe
  • H.E.S. Fjeldstad
  • R. Dechend
  • A.C. Staff

Journal

  • Journal of Reproductive Immunology

Citation

  • J Reprod Immunol 146: 103331

Abstract

  • Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation.


DOI

doi:10.1016/j.jri.2021.103331