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Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs

Authors

  • A. Leutz
  • O. Pless
  • M. Lappe
  • G. Dittmar
  • E. Kowenz-Leutz

Journal

  • Transcription

Citation

  • Transcr 2 (1): 3-8

Abstract

  • C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.


DOI

doi:10.4161/trns.2.1.13510