Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs
Authors
- A. Leutz
- O. Pless
- M. Lappe
- G. Dittmar
- E. Kowenz-Leutz
Journal
- Transcription
Citation
- Transcr 2 (1): 3-8
Abstract
C/EBPs regulate tissue and cell type specific gene expression, proliferation and differentiation control. C/EBPs assist in energy metabolism, female reproduction, innate immunity, inflammation, senescence and the development of neoplasms. How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs.