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CTGF/CCN2 has a possible detrimental role in the inflammation and the remyelination failure in the early stages of multiple sclerosis

Authors

  • L. Fuchs
  • K. Mausner-Fainberg
  • A. Luban
  • S.E. Asseyer
  • M. Golan
  • M. Benhamou
  • I. Volovitz
  • K. Regev
  • I. Vigiser
  • Y. Piura
  • H. Kolb
  • F. Paul
  • A. Karni

Journal

  • Journal of Neuroimmunology

Citation

  • J Neuroimmunol 371: 577936

Abstract

  • Connective tissue growth factor (CTGF/CCN2) is a proinflammatory and an oligodendrocyte-differentiating blocking agent. It is found in MS lesions, which raises the possibility of involvement in MS pathogenesis. We found that its CSF and serum levels were higher in RR-MS patients than in controls and for serum compared to PP and SP-MS. Immune cells of both RR-MS and controls secreted CTGF/CCN2, which was enhanced by CD3/CD28 stimulation or by LPS. Anti-CTGF treatment of mice with experimental autoimmune encephalitis ameliorated its clinical severity. CTGF/CCN2 may play a role in the immune pathogenesis of MS and in remyelination failure in early stages of MS.


DOI

doi:10.1016/j.jneuroim.2022.577936