Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis
Authors
- R.P. Zinzen
- E.E. Furlong
Journal
- Genome Biology
Citation
- Genome Biol 9 (11): 240
Abstract
Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.