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Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis

Authors

  • R.P. Zinzen
  • E.E. Furlong

Journal

  • Genome Biology

Citation

  • Genome Biol 9 (11): 240

Abstract

  • Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.


DOI

doi:10.1186/gb-2008-9-11-240