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The dual role of serotonin in colorectal cancer

Authors

  • V. Kannen
  • M. Bader
  • J.Y. Sakita
  • S.A. Uyemura
  • J.A. Squire

Journal

  • Trends in Endocrinology and Metabolism

Citation

  • Trends Endocrinol Metab 31 (8): 611-625

Abstract

  • Serotonin (5-HT) has complex effects on the central nervous system (CNS), neuroendocrine mechanisms, immunological reactions, intestinal microbiome, and cancer. It has been associated with more severe signs and symptoms of colitis, as well as promoting colorectal cancer (CRC) cells toward expansion. However, recent findings revealed that impairments in 5-HT synthesis lead to high levels of DNA damage in colonocytes, which is linked with inflammatory reactions promoting the development of CRC. Here, we review the diverse roles of 5-HT in intestinal homeostasis and in CRC and discuss how improved understanding of the modulation of the 5-HT pathway could be helpful for the design of novel anticancer therapies.


DOI

doi:10.1016/j.tem.2020.04.008