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An embedded subnetwork of highly active neurons in the neocortex

Authors

  • L. Yassin
  • B.L. Benedetti
  • J.S. Jouhanneau
  • J.A. Wen
  • J.F.A. Poulet
  • A.L. Barth

Journal

  • Neuron

Citation

  • Neuron 68 (6): 1043-1050

Abstract

  • Unbiased methods to assess the firing activity of individual neurons in the neocortex have revealed that a large proportion of cells fire at extremely low rates (<0.1 Hz), both in their spontaneous and evoked activity. Thus, firing in neocortical networks appears to be dominated by a small population of highly active neurons. Here, we use a fosGFP transgenic mouse to examine the properties of cells with a recent history of elevated activity. FosGFP-expressing layer 2/3 pyramidal cells fired at higher rates compared to fosGFP(-) neurons, both in vivo and in vitro. Elevated activity could be attributed to increased excitatory and decreased inhibitory drive to fosGFP(+) neurons. Paired-cell recordings indicated that fosGFP(+) neurons had a greater likelihood of being connected to each other. These findings indicate that highly active, interconnected neuronal ensembles are present in the neocortex and suggest these cells may play a role in the encoding of sensory information.


DOI

doi:10.1016/j.neuron.2010.11.029