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ERAD: the long road to destruction

Authors

  • B. Meusser
  • C. Hirsch
  • E. Jarosch
  • T. Sommer

Journal

  • Nature Cell Biology

Citation

  • Nat Cell Biol 7 (8): 766-772

Abstract

  • Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or unassembled proteins from the ER. ERAD targets are selected by a quality control system within the ER lumen and are ultimately destroyed by the cytoplasmic ubiquitin-proteasome system (UPS). The spatial separation between substrate selection and degradation in ERAD requires substrate transport from the ER to the cytoplasm by a process termed dislocation. In this review, we will summarize advances in various aspects of ERAD and discuss new findings on how substrate dislocation is achieved.


DOI

doi:10.1038/ncb0805-766