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Genome engineering in rodents - status quo and perspectives

Authors

  • R. Kühn

Journal

  • Laboratory Animals

Citation

  • Lab Anim 56 (1): 83-87

Abstract

  • The introduction of the CRISPR-Cas9 system in 2013 has revolutionized experimental genetics in mice and rats. This commentary gives an overview on the use of CRISPR either for gene editing in the germline or for editing and beyond editing in somatic cells. Future perspectives are opened by emerging CRISPR technologies that could enable genome engineering at larger scale.


DOI

doi:10.1177/00236772211051842