folder

Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment

Authors

  • S. Kurup
  • A. Abramsson
  • J.P. Li
  • U. Lindahl
  • L. Kjellen
  • C. Betsholtz
  • H. Gerhardt
  • D. Spillmann

Journal

  • Biochemical Society Transactions

Citation

  • Biochem Soc Trans 34 (3): 454-455

Abstract

  • HS (heparan sulphate) plays a key role in angiogenesis, by interacting with growth factors required in the process. It has been proposed that HS controls the diffusion, and thus the availability, of platelet-derived growth factor B that is needed for pericyte recruitment around newly formed capillaries. The present paper summarizes our studies on the importance of HS structure in this regulatory process.


DOI

doi:10.1042/BST0340454