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Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin

Authors

  • G. Kronenberg
  • V. Mosienko
  • K. Gertz
  • N. Alenina
  • R. Hellweg
  • F. Klempin

Journal

  • European Archives of Psychiatry and Clinical Neuroscience

Citation

  • Eur Arch Psychiatry Clin Neurosci 266 (3): 281-284

Abstract

  • The interplay between BDNF signaling and the serotonergic system remains incompletely understood. Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Surprisingly, hippocampal BDNF was significantly elevated in Tph2 (-/-) mice, whereas no significant changes were observed in SERT(-/-) mice. Furthermore, BDNF levels were increased in the prefrontal cortex of Tph2 (-/-) but not of SERT(-/-) mice. Our results emphasize the interaction between serotonin signaling and BDNF. Complete lack of brain serotonin induces BDNF expression.


DOI

doi:10.1007/s00406-015-0611-3