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Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia

Authors

  • L. Ehrlich
  • A. Hoeller
  • M. Golic
  • F. Herse
  • F.H. Perschel
  • W. Henrich
  • R. Dechend
  • B. Huppertz
  • S. Verlohren

Journal

  • Hypertension in Pregnancy

Citation

  • Hypertens Pregnancy 36 (2): 175-185

Abstract

  • OBJECTIVE: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). METHODS: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.


DOI

doi:10.1080/10641955.2017.1291673