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Involvement of claudins in zebrafish brain ventricle morphogenesis

Authors

  • J. Zhang
  • M. Liss
  • H. Wolburg
  • I.E. Blasig
  • S. Abdelilah-Seyfried

Journal

  • Annals of the New York Academy of Sciences

Citation

  • Ann N Y Acad Sci 1257 (1): 193-198

Abstract

  • Zebrafish brain ventricle morphogenesis involves an initial circulation-independent opening followed by a blood flow- and circulation-dependent expansion process. Zebrafish claudin-5a is required for the establishment of a neuroepithelial-ventricular barrier, which maintains the hydrostatic pressure within the ventricular cavity, thereby contributing to brain ventricle opening and expansion. In mammalia, several claudin family members, including claudin-3 and claudin-5, are expressed within microvessel endothelial cells of the blood-brain barrier. Whether zebrafish brain ventricle morphogenesis provides a model for studying these claudins during early embryonic development was unknown. This review focuses on the expression and function of these zebrafish claudins during brain ventricle morphogenesis.


DOI

doi:10.1111/j.1749-6632.2012.06507.x