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It's the peptide-MHC affinity, stupid

Authors

  • T. Kammertoens
  • T. Blankenstein

Journal

  • Cancer Cell

Citation

  • Canc Cell 23 (4): 429-431

Abstract

  • Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy.


DOI

doi:10.1016/j.ccr.2013.04.004