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Keep them close: PRC2 poises enhancer-promoter interactions at anterior neuronal genes

Authors

  • Giulia Caglio
  • E. Torlai Triglia
  • A. Pombo

Journal

  • Cell Stem Cell

Citation

  • Cell Stem Cell 20 (5): 573-575

Abstract

  • Enhancers exist in different epigenetic states: active, primed, or poised. However, it is not yet understood how the different enhancer states influence gene activation. In this issue of Cell Stem Cell, Cruz-Molina et al. (2017) unravel how poised enhancers activate anterior neural genes and the role of Polycomb proteins in enhancer-promoter contacts.


DOI

doi:10.1016/j.stem.2017.04.006